HMOX2

Heme oxygenase 2 · P30519 · HMOX2 on Sugi Atlas →

3,553 patent compounds predicted against HMOX2, 2,602 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tivantinib (SCHEMBL44902)	1.00	1/20
Tivantinib (SCHEMBL44944)	1.00	1/20
Tivantinib (SCHEMBL45306)	1.00	1/20
Tivantinib (SCHEMBL224883)	1.00	1/20
Tivantinib (SCHEMBL1395795)	1.00	1/20
Tivantinib (SCHEMBL2036414)	1.00	1/20
Tivantinib (SCHEMBL12043258)	1.00	1/20
Hydrochloric Acid (SCHEMBL9996054)	0.97	1/20
Tivantinib (SCHEMBL2015821)	0.92	1/20
SCHEMBL2344229	0.88	1/20
SCHEMBL3689556	0.88	1/20
SCHEMBL3689562	0.88	1/20
SCHEMBL2879596	0.87	1/20
SCHEMBL2879812	0.87	1/20
SCHEMBL3114656	0.87	1/20
SCHEMBL3120542	0.87	1/20
SCHEMBL3581172	0.85	1/20
SCHEMBL10057610	0.81	1/20
SCHEMBL10057611	0.81	1/20
SCHEMBL1395759	0.80	1/20

Clinical trials — most relevant to HMOX2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy	PHASE4	WITHDRAWN
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Carbon Monoxide Therapy for Severe Pulmonary Arterial Hypertension	PHASE1/PHASE2	WITHDRAWN
Heme Arginate in Cardiac Surgery Patients	PHASE2	COMPLETED
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)	PHASE2	UNKNOWN
Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial	PHASE1/PHASE2	UNKNOWN
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy	PHASE2	RECRUITING
Hemin in Healthy Subjects	PHASE1	COMPLETED
Effects of Heme Arginate in Healthy Male Subjects	PHASE1	COMPLETED
Carbon Monoxide to Prevent Lung Inflammation	PHASE1	COMPLETED
Nitrite Infusion Studies	PHASE1	COMPLETED
Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN	nan	COMPLETED
Relationship Between Heme Oxygenase 1 Enzyme Level and Coronary SYNTAX Score	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy	nan	RECRUITING
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection	nan	UNKNOWN
Effect Inhaled Nitric Oxide in Adult Liver Transplant	nan	NOT_YET_RECRUITING
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy	nan	COMPLETED
FFR Versus iFR in Assessment of Hemodynamic Lesion Significance	nan	UNKNOWN
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Effects of Hypoxic Breathwork	nan	RECRUITING
Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC in Subjects With COVID-19	nan	COMPLETED
Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC as an Immune System Enhancer Along With Vaccination Against COVID-19	nan	WITHDRAWN
Short-Term Broccoli Supplementation and Acute Oxidative Stress Recovery	nan	COMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features	nan	UNKNOWN
Reresveratrol Administered to Healthy Male Subjects	nan	COMPLETED
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HMOX2 binder may also engage these)

Protein	Name	Similarity
Q2PG53	—	1.000	Q2PG53 →
P23711	—	1.000	P23711 →
O70252	—	1.000	O70252 →
P43242	—	0.997	P43242 →
O73688	—	0.993	O73688 →
P14791	—	0.983	P14791 →
Q8YVS7	—	0.982	Q8YVS7 →
P51271	—	0.980	P51271 →
P07997	—	0.977	P07997 →
P10759	—	0.977	P10759 →
A9JS49	—	0.977	A9JS49 →
B3M1E1	—	0.976	B3M1E1 →
Q9C9L4	—	0.976	Q9C9L4 →
C0NLX2	—	0.976	C0NLX2 →
Q6IVA4	—	0.976	Q6IVA4 →
P13196	—	0.975	P13196 →
Q28056	—	0.975	Q28056 →
AMPD1	AMP deaminase 1	0.975	landscape →
AMPD3	AMP deaminase 3	0.975	landscape →
Q7ZU90	—	0.975	Q7ZU90 →
Q5R9R9	—	0.975	Q5R9R9 →
Q00578	—	0.975	Q00578 →
Q16W06	—	0.975	Q16W06 →
Q922E4	—	0.975	Q922E4 →
O78497	—	0.975	O78497 →
Q69XJ4	—	0.974	Q69XJ4 →
Q9WVK4	—	0.974	Q9WVK4 →
Q01559	—	0.974	Q01559 →
O45380	—	0.974	O45380 →
Q5K2C1	—	0.974	Q5K2C1 →