Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 14/20 | 0.47 |
| ▸ | ACE | P12821 | 8/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18175793 | 0.88 | CTSS (0.46) | CTSSCTSKATMMMEACE | |
| SCHEMBL9974745 | 0.87 | MME (0.61) | CTSSCTSKATMMMEACE | |
| SCHEMBL18597975 | 0.87 | MME (0.61) | CTSSCTSKATMMMEACE | |
| SCHEMBL9974741 | 0.87 | MME (0.61) | CTSSCTSKATMMMEACE | |
| SCHEMBL9963896 | 0.87 | MME (0.61) | CTSSCTSKATMMMEACE | |
| SCHEMBL16770399 | 0.85 | MME (0.67) | MMEACE | |
| SCHEMBL9929551 | 0.84 | MME (0.66) | CTSSCTSKATMMMEACE | |
| SCHEMBL18668834 | 0.80 | CTSS (0.58) | CTSSCTSKATMACEAPP | |
| SCHEMBL21074186 | 0.80 | CTSS (0.58) | CTSSCTSKATMACEAPP | |
| SCHEMBL1531592 | 0.80 | CTSS (0.62) | CTSSCTSKATMMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045443-B2 | Nitric oxide donor neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-06-02 | — | — | US | disclosed |