Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 13/20 | 0.45 |
| ▸ | ACE | P12821 | 8/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537926 | 0.88 | MME (0.47) | MMEACE | |
| SCHEMBL16770396 | 0.88 | CTSS (0.49) | CTSSCTSKMMEACEATM | |
| SCHEMBL16768805 | 0.86 | MME (0.61) | MMEACE | |
| SCHEMBL9963896 | 0.83 | MME (0.61) | CTSSCTSKMMEACEATM | |
| SCHEMBL9974741 | 0.83 | MME (0.61) | CTSSCTSKMMEACEATM | |
| SCHEMBL9974745 | 0.83 | MME (0.61) | CTSSCTSKMMEACEATM | |
| SCHEMBL18597975 | 0.83 | MME (0.61) | CTSSCTSKMMEACEATM | |
| SCHEMBL3303326 | 0.82 | CTSS (0.53) | CTSSCTSKACEATM | |
| SCHEMBL3303330 | 0.82 | CTSS (0.53) | CTSSCTSKACEATM | |
| SCHEMBL17164946 | 0.81 | MME (0.50) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855464-B1 | NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2016-10-26 | — | — | EP | disclosed |