Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271938 | 0.87 | APLNR (0.46) | APLNRMEN1KMT2ACRHR1GRIN2B | |
| SCHEMBL20563315 | 0.86 | TAAR1 (0.53) | — | |
| SCHEMBL6123805 | 0.83 | APLNR (0.61) | APLNRHMGCR | |
| SCHEMBL21222989 | 0.82 | APLNR (0.45) | APLNRMEN1KMT2ACRHR1GRIN2B | |
| SCHEMBL21313905 | 0.82 | APLNR (0.45) | APLNRMEN1KMT2ACRHR1GRIN2B | |
| SCHEMBL3162756 | 0.82 | APLNR (0.45) | APLNRMEN1KMT2ACRHR1GRIN2B | |
| SCHEMBL23055180 | 0.81 | PDE2A (0.47) | — | |
| SCHEMBL21222822 | 0.81 | MEN1 (0.45) | MEN1KMT2A | |
| SCHEMBL30488628 | 0.81 | MEN1 (0.45) | MEN1KMT2A | |
| SCHEMBL16961512 | 0.80 | GPR3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |