Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.49 |
| ▸ | RXRB | P28702 | 5/20 | 0.49 |
| ▸ | RXRG | P48443 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | ADH5 | P11766 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182393 | 0.90 | RXRA (0.51) | RXRARXRBRXRGMEN1NPC1 | |
| SCHEMBL16775447 | 0.89 | MEN1 (0.50) | RXRARXRBMEN1NPC1RAB9A | |
| SCHEMBL16775446 | 0.83 | RXRA (0.42) | RXRARXRBRXRGP2RY14ADH5 | |
| SCHEMBL182269 | 0.82 | RXRA (0.49) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL182330 | 0.81 | TUBB4A (0.48) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL182600 | 0.81 | BCL2L1 (0.47) | ADH5COMTNOTUM | |
| SCHEMBL2712103 | 0.81 | AURKA (0.45) | RXRARXRBRXRGADH5DHODH | |
| SCHEMBL17125394 | 0.80 | MEN1 (0.65) | RXRARXRBRXRGMEN1NPC1 | |
| SCHEMBL2712235 | 0.79 | KMT2A (0.58) | RXRARXRBMEN1NPC1RAB9A | |
| SCHEMBL2708139 | 0.79 | TUBB4A (0.53) | RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051342-B2 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases | PTC THERAPEUTICS, INC. (US) | 2015-06-09 | — | — | US | disclosed |