Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181092 | 0.88 | KMO (0.45) | KMOMAP2K4MRGPRX4RXRARXRB | |
| SCHEMBL16775444 | 0.86 | BCL2L1 (0.49) | MAP2K4TP53RXRARXRBMAPK14 | |
| SCHEMBL181683 | 0.85 | KMO (0.51) | KMOMRGPRX4TP53RXRARXRB | |
| SCHEMBL10194261 | 0.81 | KMO (0.49) | KMOMAP2K4MRGPRX4RXRARXRB | |
| SCHEMBL181781 | 0.81 | MRGPRX4 (0.44) | KMOMRGPRX4RXRARXRBERN1 | |
| SCHEMBL10194254 | 0.80 | KMO (0.51) | KMORXRARXRBERN1 | |
| SCHEMBL2710952 | 0.80 | KMO (0.47) | KMOMAP2K4RXRARXRBKDM4C | |
| SCHEMBL16775442 | 0.79 | METTL3 (0.49) | KMORXRARXRBLMNAGAA | |
| SCHEMBL2710097 | 0.78 | KMO (0.49) | KMOMAP2K4RXRARXRBLMNA | |
| SCHEMBL16775452 | 0.78 | KMO (0.43) | KMORXRARXRBMAPK14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051342-B2 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases | PTC THERAPEUTICS, INC. (US) | 2015-06-09 | — | — | US | disclosed |