Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.35 |
| ▸ | HACL2 | A1L0T0 | 1/20 | 0.35 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.35 |
| ▸ | GTPBP10 | A4D1E9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775852 | 0.85 | NTRK1 (0.41) | FYNCSF1RKITCA2CA9 | |
| SCHEMBL16775831 | 0.85 | KCNH2 (0.41) | ADORA2AKDM1AFYNCA2CA9 | |
| SCHEMBL16775828 | 0.85 | PIKFYVE (0.37) | DHODHADORA2AKDM1AFYNKIT | |
| SCHEMBL16776322 | 0.84 | NPC1 (0.44) | MAPTFYNKITCA2CA9 | |
| SCHEMBL16775877 | 0.84 | LMNA (0.41) | DHODHADORA2AFYNCA2CA9 | |
| SCHEMBL16775844 | 0.83 | NTRK1 (0.40) | FYNCSF1RKITCA2CA9 | |
| SCHEMBL16775851 | 0.83 | SMN1; SMN2 (0.37) | ADORA2AKDM1AALDH1A1MAPTFYN | |
| SCHEMBL16775820 | 0.83 | PHGDH (0.47) | ADORA2AKMOPHGDH | |
| SCHEMBL16775893 | 0.83 | MAPT (0.46) | DHODHADORA2AKDM1AMAPTFYN | |
| SCHEMBL16775840 | 0.82 | PIKFYVE (0.37) | DHODHADORA2AFYNKITCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | DHODH 975/4885ADORA2A 2325/4885KDM1A 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.