Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775911 | 0.88 | RPS6KA3 (0.43) | RPS6KA3RPS6KA2CNR1CNR2 | |
| SCHEMBL16776006 | 0.86 | CNR1 (0.38) | RPS6KA3RPS6KA2PRKCIKITJAK2 | |
| SCHEMBL16775852 | 0.86 | NTRK1 (0.41) | RPS6KA3RPS6KA2KIT | |
| SCHEMBL16775844 | 0.85 | NTRK1 (0.40) | RPS6KA3RPS6KA2KIT | |
| SCHEMBL16776007 | 0.85 | RPS6KA2 (0.42) | RPS6KA3RPS6KA2PRKCIKITJAK2 | |
| SCHEMBL16776000 | 0.84 | PRKCI (0.39) | RPS6KA3RPS6KA2PRKCIKITJAK2 | |
| SCHEMBL16776211 | 0.84 | RPS6KA3 (0.43) | RPS6KA3RPS6KA2KITABL1 | |
| SCHEMBL16776005 | 0.82 | KARS1 (0.50) | PRKCIKITJAK2ABL1BCR | |
| SCHEMBL16776060 | 0.82 | FGFR4 (0.43) | RPS6KA3RPS6KA2PRKCIJAK2TRPV3 | |
| SCHEMBL16775995 | 0.82 | BRAF (0.41) | RPS6KA3RPS6KA2CNR1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | RPS6KA3 2368/4885RPS6KA2 2318/4885PRKCI 2015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.