Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 8/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776160 | 0.90 | KARS1 (0.40) | KARS1FGFR4PRKD1PRKD2 | |
| SCHEMBL16776159 | 0.87 | KARS1 (0.46) | KARS1FGFR4RPS6KA3RPS6KA2PRKD1 | |
| SCHEMBL16776163 | 0.84 | FGFR4 (0.40) | KARS1FGFR4PRKD1PRKD2FAAH | |
| SCHEMBL16776013 | 0.82 | FGFR4 (0.44) | KARS1FGFR4RPS6KA3RPS6KA2FAAH | |
| SCHEMBL16776110 | 0.82 | KARS1 (0.39) | KARS1FGFR4RPS6KA3RPS6KA2FAAH | |
| SCHEMBL16776129 | 0.80 | FGFR4 (0.42) | KARS1FGFR4RPS6KA2FAAHCYP2C9 | |
| SCHEMBL16775937 | 0.80 | FGFR4 (0.42) | KARS1FGFR4RPS6KA3RPS6KA2FAAH | |
| SCHEMBL16775864 | 0.79 | FGFR4 (0.44) | FGFR4RPS6KA3RPS6KA2FAAHADORA2A | |
| SCHEMBL16776089 | 0.79 | FGFR4 (0.46) | FGFR4RPS6KA3RPS6KA2FAAHLMNA | |
| SCHEMBL16776194 | 0.79 | FGFR4 (0.42) | KARS1FGFR4PRKD1PRKD2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | KARS1 1760/4885FGFR4 1754/4885RPS6KA3 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.