Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618765 | 0.92 | FAAH (0.39) | FAAHFGFR4RPS6KA2PIK3CAMTOR | |
| SCHEMBL17618750 | 0.92 | FAAH (0.39) | FAAHFGFR4HCRTR2RPS6KA2PIK3CA | |
| SCHEMBL17618734 | 0.91 | FGFR4 (0.40) | FAAHFGFR4HCRTR1HCRTR2RPS6KA2 | |
| SCHEMBL16776278 | 0.89 | HCRTR1 (0.37) | HCRTR1HCRTR2PIK3CAMTORCYP2C9 | |
| SCHEMBL16776289 | 0.87 | FAAH (0.35) | FAAHHCRTR1HCRTR2EGFRGSK3B | |
| SCHEMBL17618529 | 0.87 | FAAH (0.38) | FAAHFGFR4HCRTR2RPS6KA2PIK3CA | |
| SCHEMBL17618572 | 0.85 | ABL1 (0.37) | FAAHFGFR4DYRK1ACYP2C9ABL1 | |
| SCHEMBL17618525 | 0.85 | FAAH (0.40) | FAAHFGFR4RPS6KA2PIK3CAMTOR | |
| SCHEMBL16776273 | 0.85 | FAAH (0.36) | FAAHHCRTR1HCRTR2GSK3BDYRK1A | |
| SCHEMBL16776254 | 0.85 | FAAH (0.43) | FAAHFGFR4HCRTR1HCRTR2CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | FAAH 977/4885FGFR4 1754/4885HCRTR1 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.