Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776322 | 0.89 | NPC1 (0.44) | MEN1KMT2ASMN1; SMN2CA2CA9 | |
| SCHEMBL16776338 | 0.88 | MCHR1 (0.44) | MCHR1MEN1KMT2ASMN1; SMN2CA2 | |
| SCHEMBL16776340 | 0.88 | MCHR1 (0.40) | MCHR1MEN1KMT2ASMN1; SMN2CA2 | |
| SCHEMBL19365248 | 0.87 | MCHR1 (0.41) | MCHR1MEN1POLBKMT2AEPHB4 | |
| SCHEMBL16776339 | 0.86 | EPHX2 (0.43) | MCHR1MEN1KMT2ASMN1; SMN2CA2 | |
| SCHEMBL16776329 | 0.86 | FYN (0.42) | POLBHTR2CSMN1; SMN2CA2CA9 | |
| SCHEMBL19365247 | 0.85 | MCHR1 (0.39) | MCHR1MEN1POLBKMT2AHTR2C | |
| SCHEMBL16785648 | 0.85 | EPHB4 (0.44) | MEN1POLBKMT2AEPHB4SMN1; SMN2 | |
| SCHEMBL16776367 | 0.84 | NPC1 (0.44) | MEN1KMT2AHTR2CCA2CA9 | |
| SCHEMBL16776321 | 0.83 | FYN (0.44) | MEN1KMT2AHTR2CSMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MCHR1 4256/4885MEN1 3676/4885POLB 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.