Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 13/20 | 0.35 |
| ▸ | CLK2 | P49760 | 8/20 | 0.34 |
| ▸ | WNT1 | P04628 | 5/20 | 0.33 |
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 7/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776407 | 0.93 | CREBBP (0.44) | BRD4CREBBPDYRK1ACLK2WNT1 | |
| SCHEMBL16776413 | 0.89 | DYRK1A (0.41) | DYRK1AWNT1GSK3B | |
| SCHEMBL16776425 | 0.88 | BRD4 (0.35) | BRD4CREBBPDYRK1ACLK2WNT1 | |
| SCHEMBL16776420 | 0.87 | PIM1 (0.34) | BRD4CREBBPDYRK1AWNT1GSK3B | |
| SCHEMBL16776410 | 0.85 | CREBBP (0.38) | BRD4CREBBPBRAFRPS6KA3RPS6KA2 | |
| SCHEMBL19670659 | 0.85 | DYRK1A (0.34) | DYRK1ACLK2WNT1GSK3BBRAF | |
| SCHEMBL16776017 | 0.82 | GSK3B (0.38) | DYRK1ACLK2GSK3BKDM4ECLK3 | |
| SCHEMBL16776108 | 0.81 | CREBBP (0.45) | BRD4CREBBPDYRK1AWNT1GSK3B | |
| SCHEMBL16776236 | 0.81 | PRMT5 (0.38) | BRD4CREBBPDYRK1ACLK2GSK3B | |
| SCHEMBL16776422 | 0.81 | CREBBP (0.40) | BRD4CREBBPDYRK1ACLK2WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | BRD4 180/4885CREBBP 528/4885DYRK1A 2623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.