Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.32 |
| ▸ | GSK3B | P49841 | 5/20 | 0.32 |
| ▸ | WNT1 | P04628 | 4/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CTPS1 | P17812 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776407 | 0.88 | CREBBP (0.44) | PIM1BRAFBRD4CREBBPSLC5A1 | |
| SCHEMBL16776413 | 0.88 | DYRK1A (0.41) | DYRK1AGSK3BWNT1 | |
| SCHEMBL16776404 | 0.87 | BRD4 (0.36) | BRAFBRD4CREBBPDYRK1AGSK3B | |
| SCHEMBL16776296 | 0.87 | RHOA (0.36) | BRAFBRD4CREBBPSLC5A1ADORA2A | |
| SCHEMBL16776403 | 0.85 | MTOR (0.35) | PIM1BRAFBRD4CREBBPHTR1A | |
| SCHEMBL19670434 | 0.85 | DYRK1A (0.34) | BRAFHTR1ADYRK1AGSK3BWNT1 | |
| SCHEMBL17618866 | 0.79 | HTR1A (0.34) | BRAFHTR1ADYRK1AGSK3BWNT1 | |
| SCHEMBL16776168 | 0.78 | DYRK1A (0.38) | DYRK1AGSK3BWNT1CYP3A4ABL1 | |
| SCHEMBL16776048 | 0.78 | ABL1 (0.35) | CYP1A2CYP3A4CYP2C9ABL1 | |
| SCHEMBL16776050 | 0.77 | PRMT5 (0.38) | PIM1DYRK1AGSK3BABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | PIM1 2799/4885BRAF 3419/4885BRD4 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.