Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 7/20 | 0.37 |
| ▸ | HTR2A | P28223 | 6/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624589 | 0.89 | TRPV1 (0.40) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL16754618 | 0.88 | TRPV1 (0.41) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL19365684 | 0.88 | TRPV1 (0.41) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL19670296 | 0.88 | TRPV1 (0.41) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL16754312 | 0.88 | TRPV1 (0.41) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL16776504 | 0.88 | MAP4K4 (0.39) | TRPV3MAP4K4PIM2 | |
| SCHEMBL17624532 | 0.84 | TRPV1 (0.40) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL19669729 | 0.84 | TRPV1 (0.40) | ALDH1A1MAPTTRPV1TRPV3HTR2C | |
| SCHEMBL19365685 | 0.83 | NAMPT (0.38) | TRPV1TRPV3HTR2CHTR2AMAP4K4 | |
| SCHEMBL16238392 | 0.81 | TRPV1 (0.42) | MAPTTRPV1HTR2CHTR2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ALDH1A1 1726/4885MAPT 267/4885TRPV1 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.