Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 2/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065335 | 0.81 | KDM4E (0.68) | KMT2AMEN1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL5476895 | 0.78 | KMT2A (0.79) | KMT2AMEN1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL1678228 | 0.77 | CFTR (0.52) | CFTRXDHKDM4ENPSR1ALDH1A1 | |
| SCHEMBL22890548 | 0.73 | KDM4E (0.41) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL17595320 | 0.73 | MCL1 (0.71) | ALDH1A1HPGDMAPTMCL1 | |
| SCHEMBL9779383 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTTDP1ADORA2AADORA1 | |
| SCHEMBL10987787 | 0.72 | ACACA (0.66) | KMT2AMEN1CFTRKDM4ENPSR1 | |
| SCHEMBL5470565 | 0.72 | KDM4E (0.66) | KMT2AMEN1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL1678198 | 0.72 | KDM4E (0.51) | KMT2AMEN1XDHKDM4ENPSR1 | |
| SCHEMBL18694708 | 0.72 | CFTR (0.62) | KMT2AMEN1CFTRKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308847-B1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC MICROCOLLECTIONS GMBH (DE) | 2014-04-02 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |