Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1677812 | 0.98 | EPHX2 (0.40) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL1678509 | 0.85 | EPHX2 (0.54) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL1677909 | 0.76 | SLC22A2 (0.43) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL657933 | 0.74 | SLC22A2 (0.42) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL1981155 | 0.69 | EPHX2 (0.51) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL136083 | 0.69 | SLC22A2 (0.48) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL660251 | 0.67 | SLC22A2 (0.52) | KMT2AMEN1SLC22A2SLC47A1ALDH1A1 | |
| SCHEMBL14055077 | 0.67 | SLC22A2 (0.41) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL28287615 | 0.67 | SLC22A2 (0.41) | EPHX2KMT2AMEN1SLC22A2SLC47A1 | |
| SCHEMBL4424458 | 0.67 | ALDH1A1 (0.54) | EPHX2KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923461-B2 | TNF-α production inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-04-12 | — | — | US | disclosed |
| US-20100016380-A1 | TNF-alpha production inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016380-A1 | TNF-alpha production inhibitors | TNF, TNFRSF1A, TNFRSF9 | EPHX2 2113/4885KMT2A 4664/4885MEN1 3108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.