Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679070 | 0.96 | KCNH2 (0.49) | KCNH2HTR2ASIGMAR1ALDH1A1CNR2 | |
| SCHEMBL1678630 | 0.93 | SIGMAR1 (0.51) | KCNH2SIGMAR1S1PR2S1PR1S1PR3 | |
| SCHEMBL1678683 | 0.91 | SIGMAR1 (0.50) | KCNH2HTR2ASIGMAR1S1PR2S1PR1 | |
| SCHEMBL1678781 | 0.87 | SIGMAR1 (0.49) | KCNH2SIGMAR1 | |
| SCHEMBL1678557 | 0.87 | MEN1 (0.46) | KCNH2SIGMAR1S1PR2S1PR1S1PR3 | |
| SCHEMBL1678751 | 0.85 | TRPA1 (0.47) | KCNH2SIGMAR1S1PR2S1PR1S1PR3 | |
| Benzene SCHEMBL28454829 | 0.84 | KCNH2 (0.68) | KCNH2HTR2ASIGMAR1ALDH1A1HSD11B1 | |
| SCHEMBL35869 | 0.84 | KCNH2 (0.68) | KCNH2HTR2ASIGMAR1ALDH1A1HSD11B1 | |
| Benzene SCHEMBL28151391 | 0.84 | KCNH2 (0.68) | KCNH2HTR2ASIGMAR1ALDH1A1HSD11B1 | |
| Formaldehyde SCHEMBL27515101 | 0.82 | KCNH2 (0.61) | KCNH2HTR2ASIGMAR1ALDH1A1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923573-B2 | Benzene compound having 2 or more substituents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-04-12 | — | — | US | disclosed |
| US-20080255111-A1 | Tissue Factor Production Inhibitor | SANKYO COMPANY LIMITED (JP) | 2008-10-16 | — | — | US | disclosed |
| US-20080004301-A1 | Benzene Compound Having 2 or More Substituents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2008-01-03 | — | — | US | disclosed |
| EP-1806332-A1 | BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS | Daiichi Sankyo Company, Limited (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1764075-A1 | TISSUE FACTOR PRODUCTION INHIBITOR | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255111-A1 | Tissue Factor Production Inhibitor | PTAFR, PLAT, TFPI | KCNH2 4863/4885HTR2A 3228/4885SIGMAR1 4028/4885 |
| US-20080004301-A1 | Benzene Compound Having 2 or More Substituents | NR1H2, NR1H3, NCOR2 | KCNH2 2251/4885HTR2A 955/4885SIGMAR1 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.