Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30858577 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL30858614 | 0.72 | CREBBP (0.39) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL8317948 | 0.70 | GAA (0.56) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL10288823 | 0.69 | PTPN1 (0.46) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL19997193 | 0.69 | PTPN1 (0.46) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL1239441 | 0.64 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDGAAGPR3 | |
| SCHEMBL19997178 | 0.64 | GSK3B (0.40) | ALDH1A1KDM4EHPGDGAAALOX12 | |
| SCHEMBL22883276 | 0.64 | HDAC1 (0.42) | HDAC1 | |
| SCHEMBL21871161 | 0.63 | ADRB1 (0.38) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL11357596 | 0.61 | GAA (0.37) | ALDH1A1MEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1988091-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KIRIN CO LTD (JP) | 2015-06-10 | — | — | EP | disclosed |