Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18007187 | 0.82 | ALDH1A1 (0.38) | ALDH1A1KDM4EUSP2SMN1; SMN2HDAC6 | |
| SCHEMBL3946301 | 0.82 | ALDH1A1 (0.41) | ALDH1A1HRH1SMN1; SMN2CASP1CASP4 | |
| SCHEMBL3945544 | 0.81 | POLB (0.42) | ALDH1A1USP2SMN1; SMN2TDP1HDAC6 | |
| SCHEMBL15416439 | 0.79 | PIK3CA (0.37) | ALDH1A1KDM4ETAAR1SMN1; SMN2CASP1 | |
| SCHEMBL2739054 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4ETAAR1HRH1USP2 | |
| SCHEMBL16909896 | 0.78 | KDM4E (0.33) | ALDH1A1KDM4ETAAR1HRH1 | |
| SCHEMBL15330361 | 0.78 | HTR3A (0.46) | ALDH1A1USP2TDP1CASP1HDAC6 | |
| SCHEMBL16793545 | 0.78 | PTPN11 (0.38) | ALDH1A1HSD17B10 | |
| SCHEMBL5525017 | 0.78 | POLB (0.57) | ALDH1A1KDM4EUSP2HDAC6TSHR | |
| SCHEMBL723901 | 0.77 | PLD1 (0.49) | ALDH1A1KDM4EUSP2TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-9957255-B2 | Benzotriazole derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-05-01 | — | — | US | disclosed |
| EP-3080107-A1 | BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SPRL (BE) | 2016-10-19 | — | — | EP | disclosed |
| US-20160297799-A1 | Benzotriazole Derivatives as Modulators of TNF Activity | UCB BIOPHARMA SPRL (BE) | 2016-10-13 | — | — | US | disclosed |
| WO-2015086508-A1 | BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2015-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297799-A1 | Benzotriazole Derivatives as Modulators of TNF Activity | TNF, NFKBIA, TNFRSF1A | ALDH1A1 1023/4885KDM4E 4091/4885TAAR1 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.