Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 7/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28510085 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2BRD4MAPK1 | |
| SCHEMBL18918395 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2BRD4MAPK1 | |
| SCHEMBL28051853 | 0.73 | IDH1 (0.38) | KDM4EALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL11575773 | 0.71 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2BRD4MAPK1 | |
| SCHEMBL16793353 | 0.70 | ALDH1A1 (1.00) | KDM4EALDH1A1SMN1; SMN2BRD4MAPK1 | |
| SCHEMBL27670029 | 0.69 | DPP4 (0.60) | ALDH1A1DPP4DPP8MAPK1HSD17B10 | |
| SCHEMBL15732165 | 0.69 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL18136496 | 0.68 | BRD4 (0.49) | KDM4EALDH1A1SMN1; SMN2DPP4BRD4 | |
| Hydrogen Sulfide SCHEMBL27639876 | 0.68 | DPP4 (0.58) | ALDH1A1DPP4DPP8MAPK1HSD17B10 | |
| SCHEMBL15717101 | 0.67 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2DPP4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |