Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 5/20 | 0.53 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30730901 | 0.82 | AURKA (0.44) | KDM4EALDH1A1SMN1; SMN2BRD4HRH3 | |
| SCHEMBL26240869 | 0.82 | CHEK1 (0.46) | KDM4EALDH1A1SMN1; SMN2BRD4HRH3 | |
| SCHEMBL29348780 | 0.82 | HRH3 (0.43) | KDM4EALDH1A1SMN1; SMN2BRD4HRH3 | |
| SCHEMBL12987761 | 0.82 | HRH3 (0.43) | KDM4EALDH1A1SMN1; SMN2BRD4HRH3 | |
| SCHEMBL12263289 | 0.82 | HPGD (0.46) | KDM4EALDH1A1SMN1; SMN2HRH3ITGB1 | |
| SCHEMBL16930872 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2BRD4PCSK9 | |
| SCHEMBL16930873 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2BRD4PCSK9 | |
| SCHEMBL21508055 | 0.80 | OPRD1 (0.47) | ALDH1A1SMN1; SMN2BRD4ITGB1ITGA4 | |
| SCHEMBL23512903 | 0.80 | HRH3 (0.44) | KDM4EALDH1A1SMN1; SMN2HRH3ITGB1 | |
| SCHEMBL21595065 | 0.78 | HRH3 (0.43) | KDM4EALDH1A1SMN1; SMN2BRD4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11608501-B2 | Methods for modifying RNA splicing | PTC THERAPEUTICS, INC. (US) | 2023-03-21 | — | — | US | disclosed |
| EP-3773552-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3774744-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019191092-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2019-10-03 | — | — | WO | disclosed |
| WO-2019191229-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2019-10-03 | — | — | WO | disclosed |
| US-8273773-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-09-25 | — | — | US | disclosed |
| US-20100021423-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2010-01-28 | — | — | US | disclosed |
| US-4170705-A | Substituted hydroxy pyridones | SANDOZ, INC. (US) | 1979-10-09 | — | — | US | disclosed |
| US-4122182-A | TRANQUILIZERS, SLEEP INDUCERS, MUSCLE RELAXANTS, NEUROLEPTICS | SANDOZ, INC. (US) | 1978-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11608501-B2 | Methods for modifying RNA splicing | RBM17, SNRPA1, SNRPE | KDM4E 1431/4885ALDH1A1 2399/4885SMN1; SMN2 701/4885 |
| US-20100021423-A1 | Heterocyclic antiviral compounds | POLR2A, RRM2B, RRP1B | KDM4E 1962/4885ALDH1A1 1136/4885SMN1; SMN2 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.