Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18108949 | 0.91 | HDAC6 (0.41) | DGAT1METAP2MAP3K5 | |
| SCHEMBL16804342 | 0.91 | METAP2 (0.39) | DGAT1EPHX2METAP2YTHDC1 | |
| SCHEMBL20525476 | 0.84 | DGAT1 (0.37) | DGAT1METAP2CHRM4FGFR1FGFR4 | |
| SCHEMBL16804322 | 0.83 | METAP2 (0.40) | EPHX2METAP2CHRM4YTHDC1FGFR1 | |
| SCHEMBL18108922 | 0.83 | HDAC6 (0.40) | METAP2CHRM4 | |
| SCHEMBL16794818 | 0.79 | MEN1 (0.38) | NR1H4EPHX2YTHDC1MEN1TP53 | |
| SCHEMBL18852703 | 0.79 | HDAC6 (0.43) | METAP2 | |
| SCHEMBL18852711 | 0.79 | METAP2 (0.41) | EPHX2METAP2YTHDC1 | |
| SCHEMBL16804406 | 0.77 | HDAC6 (0.44) | — | |
| SCHEMBL16804472 | 0.77 | METAP2 (0.39) | EPHX2METAP2CHRM4YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080125-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015087151-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-06-18 | — | — | WO | disclosed |