Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15224386 | 0.84 | HRH3 (0.50) | HRH3AKR1C3 | |
| SCHEMBL27920306 | 0.81 | HRH3 (0.46) | HRH3AKR1C3 | |
| SCHEMBL15224400 | 0.80 | HRH3 (0.51) | HRH3AKR1C3 | |
| SCHEMBL578538 | 0.80 | HRH3 (0.50) | HRH3AKR1C3 | |
| SCHEMBL3025692 | 0.79 | CKS1B (0.60) | AKR1C3OPRK1 | |
| SCHEMBL31140038 | 0.79 | AKR1C3 (0.50) | HRH3AKR1C3OPRK1 | |
| SCHEMBL1728874 | 0.79 | AKR1C3 (0.50) | HRH3AKR1C3OPRK1 | |
| SCHEMBL3266258 | 0.77 | HRH3 (0.43) | HRH3AKR1C3 | |
| SCHEMBL31140036 | 0.76 | ALDH1A1 (0.53) | EPHX1 | |
| SCHEMBL29197825 | 0.76 | ALDH1A1 (0.53) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |