Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 4/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | NR1D2 | Q14995 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16795211 | 0.91 | POLB (0.46) | KDM4EALDH1A1POLBTDP1ACHE | |
| SCHEMBL16795161 | 0.84 | POLB (0.42) | KDM4EALDH1A1POLBTDP1CHKA | |
| SCHEMBL16795319 | 0.82 | POLB (0.44) | KDM4EALDH1A1POLBTDP1CHKA | |
| SCHEMBL16121847 | 0.80 | CHKA (0.60) | KDM4ECHKACA2NCF1PRMT6 | |
| SCHEMBL21565713 | 0.79 | ALDH1A1 (0.42) | KDM4EALDH1A1POLBTDP1CHKA | |
| SCHEMBL29725194 | 0.79 | ALDH1A1 (0.42) | KDM4EALDH1A1POLBTDP1CHKA | |
| SCHEMBL16795274 | 0.78 | PARP1 (0.38) | KDM4EALDH1A1POLBACHECACNA1B | |
| SCHEMBL18579955 | 0.78 | ROCK1 (0.53) | KDM4EALDH1A1POLBTDP1CHKA | |
| SCHEMBL34461817 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL16795175 | 0.75 | KDM4E (0.70) | KDM4EALDH1A1POLBTDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |