Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CNR2 | P34972 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412847 | 0.94 | POLB (0.59) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL4412844 | 0.94 | POLB (0.59) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL10432164 | 0.94 | POLB (0.59) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL7361586 | 0.85 | ALDH1A1 (0.67) | POLBALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL5529039 | 0.84 | POLB (0.56) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL9832132 | 0.84 | POLB (0.52) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL9832138 | 0.84 | POLB (0.52) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL31186640 | 0.84 | ALDH1A1 (0.56) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL16114948 | 0.83 | POLB (0.58) | POLBALDH1A1CNR2MEN1CYP1A2 | |
| SCHEMBL10417010 | 0.83 | POLB (0.58) | POLBALDH1A1CNR2MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230364-A1 | METHODS FOR IDENTIFYING MODULATORS OF APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-22 | — | — | US | disclosed |
| US-7927816-B2 | Methods for identifying modulators of apoptosis | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-04-19 | — | — | US | disclosed |
| US-20090075292-A1 | METHODS FOR IDENTIFYING MODULATORS OF APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-03-19 | — | — | US | disclosed |
| US-7422862-B2 | Methods for identifying modulators of apoptosis | THE BURNHAM INSTITUTE (US) | 2008-09-09 | — | — | US | disclosed |
| US-20030175819-A1 | Methods for identifying modulators of apoptosis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-09-18 | — | — | US | disclosed |
| WO-2003046205-A2 | METHODS FOR IDENTIFYING MODULATORS OF APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2003-06-05 | — | — | WO | disclosed |