Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 7/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16797902 | 0.96 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL16797877 | 0.95 | SMN1; SMN2 (0.60) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL16797908 | 0.78 | HSD11B1 (0.56) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL6659375 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL11192140 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2HSD17B10HTTPKMKDM4E | |
| SCHEMBL16761070 | 0.73 | EPHX2 (0.58) | EPHX2 | |
| SCHEMBL8168957 | 0.73 | HTT (0.70) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL2975841 | 0.73 | HTT (0.70) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL13295251 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL16797886 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2HSD17B10DRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077380-A1 | THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | Sanofi (FR) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082474-A1 | THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | SANOFI (FR) | 2015-06-11 | — | — | WO | disclosed |