Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16797877 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2HSD17B10DRD4DRD3EPHX2 | |
| SCHEMBL16797902 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10DRD4DRD3EPHX2 | |
| SCHEMBL16797907 | 0.78 | SMN1; SMN2 (0.55) | HSD11B1SMN1; SMN2HSD17B10DRD4DRD3 | |
| SCHEMBL21581203 | 0.76 | DRD4 (0.59) | SMN1; SMN2HSD17B10DRD4DRD3ALDH1A1 | |
| SCHEMBL18390864 | 0.75 | HSD11B1 (0.73) | HSD11B1SMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL17986229 | 0.74 | DRD4 (0.60) | SMN1; SMN2HSD17B10DRD4DRD3ALDH1A1 | |
| SCHEMBL2790694 | 0.73 | MC4R (0.55) | HSD11B1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3396545 | 0.73 | MC4R (0.55) | HSD11B1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL11192140 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2HSD17B10ALDH1A1LMNATSHR | |
| SCHEMBL3129900 | 0.73 | HSD11B1 (1.00) | HSD11B1SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077380-A1 | THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | Sanofi (FR) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082474-A1 | THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | SANOFI (FR) | 2015-06-11 | — | — | WO | disclosed |