Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.52 |
| ▸ | DRD3 | P35462 | 7/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | DRD5 | P21918 | 4/20 | 0.49 |
| ▸ | ME2 | P23368 | 1/20 | 0.47 |
| ▸ | ME1 | P48163 | 1/20 | 0.47 |
| ▸ | ME3 | Q16798 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644981 | 0.77 | MAPT (0.66) | DRD4DRD3DRD2DRD5ME2 | |
| SCHEMBL844082 | 0.76 | GAA (0.52) | DRD4DRD3DRD2DRD5EPHX2 | |
| SCHEMBL16797864 | 0.75 | DRD4 (0.59) | DRD4DRD3DRD2DRD5ME2 | |
| SCHEMBL11988947 | 0.75 | SMO (0.52) | DRD4DRD3DRD2DRD5DRD1 | |
| SCHEMBL19299999 | 0.73 | LMNA (0.71) | DRD3DRD2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3086082 | 0.73 | AOC3 (0.54) | SMOALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17221698 | 0.72 | CYP11B1 (0.57) | HTTSMOALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL30827430 | 0.72 | CYP11B1 (0.57) | HTTSMOALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL857231 | 0.72 | CYP11B1 (0.57) | HTTSMOALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL987818 | 0.72 | AOC3 (0.55) | SMOALDH1A1KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077380-A1 | THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | Sanofi (FR) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082474-A1 | THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | SANOFI (FR) | 2015-06-11 | — | — | WO | disclosed |