Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.55 |
| ▸ | LCK | P06239 | 18/20 | 0.55 |
| ▸ | BTK | Q06187 | 4/20 | 0.55 |
| ▸ | EGFR | P00533 | 10/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30161269 | 1.00 | JAK3 (0.55) | JAK3LCKBTKEGFR | |
| SCHEMBL21946880 | 0.79 | JAK3 (0.70) | JAK3LCKBTKEGFR | |
| SCHEMBL25598953 | 0.79 | JAK3 (0.70) | JAK3LCKBTKEGFR | |
| SCHEMBL30165820 | 0.78 | JAK3 (0.50) | JAK3LCKBTKEGFR | |
| SCHEMBL25603500 | 0.78 | JAK3 (0.69) | JAK3LCKBTKEGFR | |
| SCHEMBL30165801 | 0.78 | JAK3 (0.54) | JAK3LCKBTKEGFR | |
| SCHEMBL30165821 | 0.78 | JAK3 (0.54) | JAK3LCKBTKEGFR | |
| SCHEMBL30165829 | 0.78 | JAK3 (0.51) | JAK3LCKBTKEGFR | |
| SCHEMBL29931205 | 0.76 | JAK3 (0.59) | JAK3LCKBTKEGFR | |
| SCHEMBL28647032 | 0.76 | JAK3 (0.59) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113412259-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2021-09-17 | — | — | CN | disclosed |
| EP-3077388-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics, LLC (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015084998-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2015-06-11 | — | — | WO | disclosed |