SCHEMBL16798772

SCHEMBL16798772

O=C1C(=O)N(CC=Cc2ccccc2)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 1.00
ALDH3A1 P30838 6/20 1.00
RCE1 Q9Y256 1/20 1.00
ALDH2 P05091 5/20 0.71
CES1 P23141 6/20 0.57
BCHE P06276 3/20 0.57
TGM2 P21980 1/20 0.57
CHRM1 P11229 2/20 0.55
PARK7 Q99497 1/20 0.53
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
PKM P14618 1/20 0.50
ACHE P22303 1/20 0.49
CES2 O00748 1/20 0.48
APP P05067 1/20 0.47
MAPT P10636 1/20 0.47
SNCA P37840 1/20 0.47
CHRM5 P08912 1/20 0.47
CHRM3 P20309 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16798771 1.00 ALDH1A1 (1.00) ALDH1A1ALDH3A1RCE1ALDH2CES1
SCHEMBL16798812 0.83 ALDH1A1 (1.00) ALDH1A1ALDH3A1RCE1ALDH2CES1
SCHEMBL16798810 0.83 ALDH1A1 (1.00) ALDH1A1ALDH3A1RCE1ALDH2CES1
SCHEMBL950200 0.82 ALDH1A1 (0.69) ALDH1A1ALDH3A1RCE1ALDH2CES1
SCHEMBL950201 0.82 ALDH1A1 (0.69) ALDH1A1ALDH3A1RCE1ALDH2CES1
SCHEMBL23847348 0.82 ALDH1A1 (0.69) ALDH1A1ALDH3A1RCE1ALDH2CHRM1
SCHEMBL10421306 0.82 ALDH1A1 (0.69) ALDH1A1ALDH3A1RCE1ALDH2CHRM1
SCHEMBL15215076 0.77 ALDH1A1 (0.64) ALDH1A1ALDH3A1RCE1ALDH2PARK7
SCHEMBL950088 0.77 CASP3 (0.72) ALDH1A1ALDH3A1RCE1ALDH2CES1
SCHEMBL29724215 0.77 CASP3 (0.72) ALDH1A1ALDH3A1RCE1ALDH2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015084731-A1 ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2015-06-11 WO disclosed