SCHEMBL16799733

SCHEMBL16799733

CN1CC(c2cccc(C(F)(F)F)c2)CC1=O

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 7/20 0.60
PDE4A P27815 3/20 0.51
PDE4B Q07343 1/20 0.51
PDE4C Q08493 1/20 0.51
PDE4D Q08499 1/20 0.51
DRD2 P14416 1/20 0.51
HTR2C P28335 2/20 0.49
HSD17B2 P37059 1/20 0.46
SRD5A1 P18405 1/20 0.43
GRM2 Q14416 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29728437 1.00 BRD4 (0.60) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL18129442 1.00 BRD4 (0.60) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL30591990 0.86 BRD4 (0.57) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL25636100 0.83 DRD2 (0.51) BRD4DRD2HTR2CGRM2
SCHEMBL25636537 0.82 BRD4 (0.64) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL24813384 0.80 BRD4 (0.53) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL24813390 0.80 BRD4 (0.53) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL24007585 0.79 BRD4 (0.51) BRD4PDE4APDE4BPDE4CPDE4D
SCHEMBL13063397 0.79 DRD2 (0.58) DRD2HTR2CGRM2
SCHEMBL11068920 0.77 DRD2 (0.48) DRD2HTR2CGRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023112033-A2 COMPOUNDS USEFUL FOR THE PREPARATION OF VARIOUS AGROCHEMICALS AND MARKERS THEREOF ADAMA AGAN LTD. (IL) 2023-06-22 WO disclosed
EP-3077374-A1 PYRROLIDINONES AS HERBICIDES E. I. du Pont de Nemours and Company (US) 2016-10-12 EP disclosed
WO-2015084796-A1 PYRROLIDINONES AS HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2015-06-11 WO disclosed