Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Paromomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.89 |
| ▸ | TSHR | P16473 | 1/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.87 |
| ▸ | LRAT | O95237 | 1/20 | 0.87 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paromomycin SCHEMBL691558 | 1.00 | BLM (1.00) | BLMRECQLTDP1HSD17B10TSHR | |
| Paromomycin SCHEMBL2527138 | 1.00 | BLM (1.00) | BLMRECQLTDP1HSD17B10TSHR | |
| Paromomycin SCHEMBL3355 | 1.00 | BLM (1.00) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL3696748 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL2133931 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL29628935 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL285111 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL373681 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL2133938 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Paromomycin SCHEMBL28264135 | 0.97 | BLM (0.94) | BLMRECQLTDP1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4746516-A | STORAGE STABILITY, PURITY | FARMITALIA CARLO ERBA S.P.A. (IT) | 1988-05-24 | — | — | US | claimed |
| EP-2663335-A1 | A COMPOSITION FOR THE REGENERATION OF ATROPHIC TISSUES | Medestea Internazionale S.p.A. (IT) | 2013-11-20 | — | — | EP | disclosed |
| WO-2012095702-A1 | A COMPOSITION FOR THE REGENERATION OF ATROPHIC TISSUES | MEDESTEA INTERNAZIONALE S.P.A. (IT) | 2012-07-19 | — | — | WO | disclosed |
| WO-2011050192-A1 | MODULATION OF AXON DEGENERATION | GENENTECH, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
| EP-2227083-A1 | COMPOSITION COMPRISING CALCIUM IONS AND AT LEAST ONE PROTEOLYTIC ENZYME FOR USE IN THE IN VITRO AND IN VIVO REGENERATION OF CUTANEOUS AND CONNECTIVE TISSUES | Medevice S.P.A. (IT) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009069022-A1 | COMPOSITION COMPRISING CALCIUM IONS AND AT LEAST ONE PROTEOLYTIC ENZYME FOR USE IN THE IN VITRO AND IN VIVO REGENERATION OF CUTANEOUS AND CONNECTIVE TISSUES | MEDEVICE S.P.A. (IT) | 2009-06-04 | — | — | WO | disclosed |
| EP-0412982-A1 | PAROMOMYCIN OR DERIVATIVES THEREOF FOR PARENTERAL TREATMENT OF HUMAN PARASITIC DISEASES. | ERBA CARLO SPA (IT) | 1991-02-20 | — | — | EP | disclosed |
| US-4746516-A | STORAGE STABILITY, PURITY | FARMITALIA CARLO ERBA S.P.A. (IT) | 1988-05-24 | — | — | US | disclosed |
| US-4746516-A | STORAGE STABILITY, PURITY | FARMITALIA CARLO ERBA S.P.A. (IT) | 1988-05-24 | — | — | US | disclosed |
| US-4460577-A | Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-07-17 | — | — | US | disclosed |
| US-4460577-A | Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-07-17 | — | — | US | disclosed |