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Paromomycin

Paromomycin

SCHEMBL691558

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nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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The experimentally established mechanism targets of Paromomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ BLM P54132 1/20 1.00
▸ RECQL P46063 1/20 1.00
▸ TDP1 Q9NUW8 1/20 1.00
▸ HSD17B10 Q99714 1/20 0.89
▸ TSHR P16473 1/20 0.89
▸ MEN1 O00255 1/20 0.87
▸ LRAT O95237 1/20 0.87
▸ TRPV1 Q8NER1 1/20 0.87
▸ LMNA P02545 1/20 0.81
▸ MAPT P10636 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Paromomycin SCHEMBL1680052 1.00 BLM (1.00) BLMRECQLTDP1HSD17B10TSHR
Paromomycin SCHEMBL2527138 1.00 BLM (1.00) BLMRECQLTDP1HSD17B10TSHR
Paromomycin SCHEMBL3355 1.00 BLM (1.00) BLMRECQLTDP1HSD17B10TSHR
Framycetin SCHEMBL3696748 0.99 BLM (0.98) BLMRECQLTDP1HSD17B10TSHR
Framycetin SCHEMBL2133931 0.99 BLM (0.98) BLMRECQLTDP1HSD17B10TSHR
Framycetin SCHEMBL29628935 0.99 BLM (0.98) BLMRECQLTDP1HSD17B10TSHR
Framycetin SCHEMBL285111 0.99 BLM (0.98) BLMRECQLTDP1HSD17B10TSHR
Framycetin SCHEMBL373681 0.99 BLM (0.98) BLMRECQLTDP1HSD17B10TSHR
Framycetin SCHEMBL2133938 0.99 BLM (0.98) BLMRECQLTDP1HSD17B10TSHR
Paromomycin SCHEMBL28264135 0.97 BLM (0.94) BLMRECQLTDP1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2421555-A2 NUCLEIC ACID MOLECULE The University Of York (GB) 2012-02-29 — — EP claimed
WO-2010122310-A2 NUCLEIC ACID MOLECULE THE UNIVERSITY OF YORK (GB) 2010-10-28 — — WO claimed
EP-3086646-A2 PLANTS CONTAINING BENEFICIAL ENDOPHYTES Indigo AG, Inc. (US) 2016-11-02 — — EP disclosed
WO-2015100431-A2 PLANTS CONTAINING BENEFICIAL ENDOPHYTES SYMBIOTA, INC. (US) 2015-07-02 — — WO disclosed
EP-2437596-A1 SKIN TREATMENT COMPOSITIONS Ex-Tek, LLC (US) 2012-04-11 — — EP disclosed
WO-2010141711-A1 SKIN TREATMENT COMPOSITIONS EX-TEK, LLC (US) 2010-12-09 — — WO disclosed
WO-2010009735-A2 COMBINATORIAL ANALYSIS AND REPAIR DAKO DENMARK A/S (DK) 2010-01-28 — — WO disclosed