Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Paromomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.89 |
| ▸ | TSHR | P16473 | 1/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.87 |
| ▸ | LRAT | O95237 | 1/20 | 0.87 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paromomycin SCHEMBL1680052 | 1.00 | BLM (1.00) | BLMRECQLTDP1HSD17B10TSHR | |
| Paromomycin SCHEMBL691558 | 1.00 | BLM (1.00) | BLMRECQLTDP1HSD17B10TSHR | |
| Paromomycin SCHEMBL2527138 | 1.00 | BLM (1.00) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL3696748 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL2133931 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL29628935 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL285111 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL373681 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Framycetin SCHEMBL2133938 | 0.99 | BLM (0.98) | BLMRECQLTDP1HSD17B10TSHR | |
| Paromomycin SCHEMBL28264135 | 0.97 | BLM (0.94) | BLMRECQLTDP1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4561 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| US-12465623-B2 | Use of parasites and extracellular vesicles obtained from parasites in cancer treatment | YEDITEPE UNIVERSITESI (TR) | 2025-11-11 | — | — | US | claimed |
| US-12454675-B2 | Method of increasing protein yield in mammalian cells in serum-free culture medium | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2025-10-28 | — | — | US | claimed |
| EP-4633643-A1 | USE OF BORON FOR THE TREATMENT OF LEISHMANIASIS DISEASE OF NEURONAL ORIGIN | Yeditepe Universitesi (TR) | 2025-10-22 | — | — | EP | claimed |
| EP-4633617-A1 | USE OF BORON FOR THE TREATMENT OF LEISHMANIASIS DISEASE | Yeditepe Universitesi (TR) | 2025-10-22 | — | — | EP | claimed |
| EP-3965808-B1 | USE OF PARASITES AND EXTRACELLULAR VESICLES OBTAINED FROM PARASITES IN CANCER TREATMENT | UNIV YEDITEPE (TR) | 2025-09-03 | — | — | EP | claimed |
| US-12396884-B2 | Device and method for stimulating the meibomian glands of the eyelid | TEENY CLEAN, LLC | 2025-08-26 | — | — | US | claimed |
| EP-4007583-B1 | VETERINARY COMPOSITIONS FOR PREVENTING AND/OR TREATING CRYPTOSPORIDIOSIS | CEVA SANTE ANIMALE (FR) | 2025-07-02 | — | — | EP | claimed |
| CN-120053460-A | Pharmaceutical composition for preventing or treating flavivirus infection | 雷莫内克斯生物制药有限公司 | 2025-05-30 | — | — | CN | claimed |
| US-12295967-B2 | Pharmaceutical composition for prevention or treatment of flavivirus infection | LEMONEX INC. (KR) | 2025-05-13 | — | — | US | claimed |
| US-5948416-A | LEAVE ON SKIN CARE COMPOSITION; HYDROPHOBIC STRUCTURING AGENT; HYDROPHILIC CATIONIC SURFACTANT; ACTIVE COMPOUND | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-07 | — | — | US | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5905092-A | Topical antibiotic composition providing optimal moisture environment for rapid wound healing that reduces skin contraction | VIROTEX CORPORATION REEL/FRAME (US) | 1999-05-18 | — | — | US | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5780049-A | Enhanced skin penetration system for improved topical delivery of drugs | RICHARDSON-VICKS INC. (US) | 1998-07-14 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| WO-1994006439-A1 | ANTILEISHMANIAL COMPOSITION FOR TOPICAL APPLICATION | DEPARTMENT OF THE ARMY, UNITED STATES GOVERNMENT (US) | 1994-03-31 | — | — | WO | claimed |
| EP-0435915-B1 | COMPOSITIONS FOR THE TREATMENT OF LEISHMANIASIS | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-05-26 | — | — | EP | claimed |
| EP-0435915-A1 | COMPOSITIONS FOR THE TREATMENT OF LEISHMANIASIS. | ERBA CARLO SPA (IT) | 1991-07-10 | — | — | EP | claimed |
| WO-1990003174-A1 | COMPOSITIONS FOR THE TREATMENT OF LEISHMANIASIS | NEAL, Jane, Alison +lf (GB) | 1990-04-05 | — | — | WO | claimed |