Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1359678 | 0.81 | LMNA (0.37) | LMNAALDH1A1PIK3CAMTORPIK3CB | |
| SCHEMBL1680071 | 0.74 | PIK3CA (0.42) | PIK3CAMTORPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL1681397 | 0.71 | PIK3CA (0.39) | LMNAALDH1A1PIK3CAMTORPIK3CB | |
| SCHEMBL2565055 | 0.68 | PIK3CA (0.51) | LMNAALDH1A1PIK3CAMTORPIK3CB | |
| Hydrochloric Acid SCHEMBL2565069 | 0.67 | PIK3CA (0.50) | LMNAALDH1A1PIK3CAMTORPIK3CB | |
| SCHEMBL1680093 | 0.64 | PIK3CA (0.41) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL2567788 | 0.64 | MTOR (0.49) | ALDH1A1PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL2597501 | 0.64 | MTOR (0.62) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL2571185 | 0.64 | PIK3CA (0.53) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3051889 | 0.64 | PIK3CA (0.51) | PIK3CAMTORPIK3CBPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483272-A2 | PI3K (DELTA) SELECTIVE INHIBITORS | Xcovery Holding Company LLC (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041399-A2 | PI3K (DELTA) SELECTIVE INHIBITORS | TYROGENEX, INC. (US) | 2011-04-07 | — | — | WO | disclosed |