SCHEMBL1680183

SCHEMBL1680183

COc1ccc(N(c2ccccc2)c2ccc3cc(Br)ccc3c2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.44
LMNA P02545 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CYP1A2 P05177 1/20 0.42
MAPT P10636 2/20 0.40
ALOX5 P09917 1/20 0.40
CA4 P22748 1/20 0.39
PTGES O14684 1/20 0.39
LTA4H P09960 1/20 0.39
NCEH1 Q6PIU2 1/20 0.39
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39
SLC16A3 O15427 1/20 0.38
SLC16A1 P53985 1/20 0.38
TUBB4A P04350 1/20 0.37
TUBB P07437 1/20 0.37
TUBA3C P0DPH7 1/20 0.37
TUBA1B P68363 1/20 0.37
TUBA4A P68366 1/20 0.37
TUBB4B P68371 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1680166 0.90 CYP1A2 (0.50) CYP2A6LMNAL3MBTL1CYP1A2MAPT
SCHEMBL31672318 0.88 CYP2A6 (0.56) CYP2A6LMNAL3MBTL1CYP1A2MAPT
SCHEMBL1680173 0.88 CYP2A6 (0.56) CYP2A6LMNAL3MBTL1CYP1A2MAPT
SCHEMBL13367670 0.87 CYP1A2 (0.57) CYP2A6LMNAL3MBTL1CYP1A2CA4
SCHEMBL1680170 0.87 CA4 (0.48) LMNAL3MBTL1CYP1A2MAPTALOX5
SCHEMBL12003579 0.86 HSD17B1 (0.42) CYP2A6LMNAL3MBTL1CYP1A2MAPT
SCHEMBL14414380 0.85 CYP1A2 (0.59) CYP2A6LMNACYP1A2MAPTCA4
SCHEMBL15449512 0.85 CYP2A6 (0.63) CYP2A6LMNAL3MBTL1CYP1A2MAPT
SCHEMBL23044729 0.83 CYP1A2 (0.61) CYP2A6LMNAL3MBTL1CYP1A2MAPT
SCHEMBL19564401 0.83 CYP2A6 (0.54) CYP2A6LMNAL3MBTL1CYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011041529-A2 TRI-2-NAPHTHYLAMINES ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2011-04-07 WO disclosed
WO-2011041529-A2 TRI-2-NAPHTHYLAMINES ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2011-04-07 WO disclosed