SCHEMBL1680239

CC(C)Oc1cc2cc(CC(O)(CC(C)(C)c3cc(Cl)cc4c3OCC4)C(F)(F)F)[nH]c2cn1.Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cc(C(F)(F)F)ncc2[nH]1)C(F)(F)F

nearest known ligand 0.69

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1	P04150	20/20	0.69

▸	CYP3A4	P08684	8/20	0.69

▸	PGR	P06401	13/20	0.58

▸	NR3C2	P08235	11/20	0.58

▸	KCNH2	Q12809	1/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1680240	0.90	NR3C1 (0.57)	NR3C1CYP3A4PGRNR3C2KCNH2
SCHEMBL9987961	0.89	NR3C1 (0.65)	NR3C1CYP3A4PGRNR3C2KCNH2
SCHEMBL293094	0.89	NR3C1 (0.70)	NR3C1CYP3A4PGRNR3C2
SCHEMBL291968	0.85	NR3C1 (0.75)	NR3C1CYP3A4PGRNR3C2
SCHEMBL292321	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR3C2KCNH2
SCHEMBL292562	0.81	NR3C1 (0.73)	NR3C1CYP3A4PGRNR3C2
SCHEMBL292934	0.81	NR3C1 (0.72)	NR3C1CYP3A4PGRNR3C2
SCHEMBL6382160	0.80	NR3C1 (0.59)	NR3C1CYP3A4PGRNR3C2KCNH2
SCHEMBL9987170	0.80	NR3C1 (0.75)	NR3C1CYP3A4PGRNR3C2KCNH2
SCHEMBL291699	0.80	NR3C1 (0.82)	NR3C1CYP3A4PGRNR3C2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2397140-A1	Compositions and methods for treating or preventing glaucoma or progression thereof	BAUSCH & LOMB INCORPORATED (US)	2011-12-21	—	—	EP	disclosed
EP-2061444-B1	COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, AMELIORATING, OR PREVENTING ALLERGY	BAUSCH & LOMB (US)	2011-04-20	—	—	EP	disclosed