Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893194 | 0.87 | HSD11B1 (0.47) | HSD11B1GBA1NPC1MAP4K4KDM1A | |
| SCHEMBL6057032 | 0.87 | — | — | |
| SCHEMBL8149011 | 0.87 | HSD11B1 (0.47) | HSD11B1GBA1NPC1MAP4K4KDM1A | |
| SCHEMBL16938964 | 0.81 | HSD11B1 (0.41) | HSD11B1GBA1NPC1MAP4K4NAMPT | |
| SCHEMBL16622424 | 0.81 | HSD11B1 (0.41) | HSD11B1GBA1NPC1MAP4K4NAMPT | |
| SCHEMBL3318840 | 0.81 | HSD11B1 (0.45) | HSD11B1GBA1NPC1MAP4K4NAMPT | |
| SCHEMBL84800 | 0.80 | HSD11B1 (0.43) | HSD11B1GBA1NPC1KDM4EALDH1A1 | |
| SCHEMBL793514 | 0.78 | DRD2 (0.44) | HSD11B1GBA1NPC1MEN1KMT2A | |
| SCHEMBL10930283 | 0.78 | HSD11B1 (0.42) | HSD11B1GBA1NPC1KDM4EALDH1A1 | |
| SCHEMBL21664675 | 0.78 | HSD11B1 (0.42) | HSD11B1GBA1TDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376502-B1 | THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-06-17 | — | — | EP | disclosed |