SCHEMBL1680577

SCHEMBL1680577

CCOC(=O)C(C#N)=CCl

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.62
ALDH1A1 P00352 6/20 0.52
TSHR P16473 1/20 0.52
MAPT P10636 5/20 0.49
KDM4E B2RXH2 2/20 0.49
POLB P06746 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
PTP4A1 Q93096 1/20 0.49
MIF P14174 1/20 0.49
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
NPSR1 Q6W5P4 3/20 0.48
USP2 O75604 2/20 0.48
GAA P10253 2/20 0.48
PDCD1 Q15116 1/20 0.47
CD274 Q9NZQ7 1/20 0.47
PKM P14618 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6152101 1.00 CYP2C9 (0.62) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL9545461 1.00 CYP2C9 (0.62) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL2755215 0.85 CYP2C9 (0.69) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL4906704 0.85 CYP2C9 (0.69) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL4961560 0.85 CYP2C9 (0.69) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL27638684 0.85 CYP2C9 (0.46) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL1680433 0.82 CYP2C9 (0.65) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL8025998 0.82 CYP2C9 (0.65) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL1680434 0.82 CYP2C9 (0.65) CYP2C9ALDH1A1TSHRMAPTKDM4E
SCHEMBL19355063 0.82 CYP2C9 (0.65) CYP2C9ALDH1A1TSHRMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101671270-B Method for synthesizing cyanoacetylene derivatives HANGZHOU ALLSINO CHEMICALS CO LTD 2013-07-31 CN disclosed
US-20110195999-A1 NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND NAKAMOTO KAZUTAKA 2011-08-11 US disclosed
US-7932272-B2 Antifungal agent containing heterocyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-04-26 US disclosed
CN-101671270-A Method for synthesizing cyanoacetylene derivatives HANGZHOU ALLSINO CHEMICALS CO 2010-03-17 CN disclosed
US-20090227799-A1 Novel Antimalarial Agent Containing Heterocyclic Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-09-10 US disclosed
US-20070105943-A1 Novel antifungal agent containing heterocyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2007-05-10 US disclosed
EP-1782811-A1 NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND Eisai R&D Management Co., Ltd. (JP) 2007-05-09 EP disclosed
EP-1669348-A1 NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND Eisai Co., Ltd. (JP) 2006-06-14 EP disclosed
EP-0898732-B1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING 3-HETEROAROMATIC-SUBSTITUTED ACRYLONITRILE COMPOUNDS AS CO-DEVELOPERS EASTMAN KODAK CO (US) 2005-01-26 EP disclosed
EP-0852026-B1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING ACRYLONITRILE COMPOUNDS AS CO-DEVELOPERS EASTMAN KODAK CO (US) 2000-03-01 EP disclosed
EP-0898732-A1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING 3-HETEROAROMATIC-SUBSTITUTED ACRYLONITRILE COMPOUNDS AS CO-DEVELOPERS Imation Corp. (US) 1999-03-03 EP disclosed
EP-0852026-A1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING ACRYLONITRILE COMPOUNDS AS CO-DEVELOPERS Imation Corp. (US) 1998-07-08 EP disclosed
WO-1997043690-A1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING 3-HETEROAROMATIC-SUBSTITUTED ACRYLONITRILE COMPOUNDS AS CO-DEVELOPERS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-11-20 WO disclosed
US-5635339-A 3-heteroaramatic-substituted acrylonitrile compounds as co-developers for black-and-white photothermographic and thermographic elements MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-06-03 US disclosed
WO-1997011409-A1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING ACRYLONITRILE COMPOUNDS AS CO-DEVELOPERS IMATION CORP. (US) 1997-03-27 WO disclosed
US-5545515-A ELEMENT CONTAINING SILVER REDUCING AGENT SYSTEM INCLUDING HINDERED PHENOL AND ACRYLONITRILE COMPOUND MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-08-13 US disclosed
WO-1993018035-A1 ANGIOTENSIN II RECEPTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1993-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110195999-A1 NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND ERG28, CYP51A1, XPO1 CYP2C9 1072/4885ALDH1A1 1677/4885TSHR 3875/4885
US-20090227799-A1 Novel Antimalarial Agent Containing Heterocyclic Compound XPO1, THPO, G6PD CYP2C9 3419/4885ALDH1A1 1926/4885TSHR 3836/4885
US-20070105943-A1 Novel antifungal agent containing heterocyclic compound ERG28, DPM1, CYP51A1 CYP2C9 1154/4885ALDH1A1 1459/4885TSHR 3952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.