⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720286 | 0.97 | — | — | |
| Propene SCHEMBL30544514 | 0.85 | LMNA (0.33) | — | |
| SCHEMBL16563305 | 0.85 | PTGS1 (0.33) | — | |
| SCHEMBL16563535 | 0.85 | PTGS1 (0.33) | — | |
| SCHEMBL5350622 | 0.84 | APP (0.44) | — | |
| Acrylamide SCHEMBL28947371 | 0.84 | ALDH1A1 (0.48) | — | |
| SCHEMBL16563534 | 0.84 | PTGS1 (0.32) | — | |
| SCHEMBL28151019 | 0.82 | APP (0.42) | — | |
| SCHEMBL720942 | 0.81 | — | — | |
| SCHEMBL9935746 | 0.80 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250115608-A1 | HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS | ARDELYX, INC. (US) | 2025-04-10 | — | — | US | disclosed |
| US-12209088-B2 | Hormone receptor modulators for treating metabolic conditions and disorders | ARDELYX, INC. (US) | 2025-01-28 | — | — | US | disclosed |
| CN-118812495-A | Butane sultone compound, preparation method thereof and secondary battery | 蔚来电池科技(安徽)有限公司 | 2024-10-22 | — | — | CN | disclosed |
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-09-17 | — | — | US | disclosed |
| US-12024529-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-07-02 | — | — | US | disclosed |
| WO-2024037738-A1 | HIGH PURITY SULFONATED THIOPHENE MONOMERS | HERAEUS EPURIO GMBH (DE) | 2024-02-22 | — | — | WO | disclosed |
| EP-4324866-A1 | HIGH PURITY SULFONATED THIOPHENE MONOMERS | Heraeus Epurio GmbH (DE) | 2024-02-21 | — | — | EP | disclosed |
| CN-116854681-A | Hormone receptor modulators for the treatment of metabolic conditions and disorders | 阿德利克斯股份有限公司 | 2023-10-10 | — | — | CN | disclosed |
| US-20230271981-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-08-31 | — | — | US | disclosed |
| US-11685747-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2023-06-27 | — | — | US | disclosed |
| WO-2016033486-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2016-03-03 | — | — | WO | disclosed |
| US-20160045508-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PFIZER INC. (US) | 2016-02-18 | — | — | US | disclosed |
| WO-2016024185-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | PFIZER INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| US-20150250762-A1 | NOVEL MEK INHIBITORS FOR TREATING CARDIOMYOPATHIES AND RELATED CONDITIONS | ALLOMEK THERAPEUTICS, LLC | 2015-09-10 | — | — | US | disclosed |
| US-9034861-B2 | MEK inhibitors useful in the treatment of diseases | ALLOMEK THERAPEUTICS LLC (US) | 2015-05-19 | — | — | US | disclosed |
| EP-2488507-B1 | NOVEL MEK INHIBITORS, USEFUL IN THE TREATMENT OF DISEASES | ALLOSTEM THERAPEUTICS LLC (US) | 2014-12-17 | — | — | EP | disclosed |
| EP-2488507-A2 | NOVEL MEK INHIBITORS, USEFUL IN THE TREATMENT OF DISEASES | Allostem Therapeutics LLC (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20120208859-A1 | NOVEL MEK INHIBITORS USEFUL IN THE TREATMENT OF DISEASES | ALLOSTEM THERAPEUTICS LLC (US) | 2012-08-16 | — | — | US | disclosed |
| WO-2011047055-A2 | NOVEL MEK INHIBITORS, USEFUL IN THE TREATMENT OF DISEASES | ALLOSTEM THERAPEUTICS LLC (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |