Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 19/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16812220 | 0.89 | TOP1 (0.58) | TOP1RECQLTDP1MEN1ALDH1A1 | |
| SCHEMBL16649246 | 0.87 | TOP1 (0.75) | TOP1RECQLTDP1MEN1ALDH1A1 | |
| SCHEMBL16812228 | 0.86 | TOP1 (0.56) | TOP1RECQLTDP1MEN1ALDH1A1 | |
| SCHEMBL26843370 | 0.81 | TOP1 (0.77) | TOP1RECQLTDP1MEN1ALDH1A1 | |
| SCHEMBL18251456 | 0.81 | TOP1 (0.60) | TOP1RECQLTDP1MEN1ALDH1A1 | |
| SCHEMBL16812231 | 0.81 | TOP1 (0.53) | TOP1MEN1ALDH1A1GLAKMT2A | |
| SCHEMBL14576618 | 0.81 | TOP1 (0.62) | TOP1MEN1ALDH1A1GLAKMT2A | |
| SCHEMBL15721371 | 0.81 | TOP1 (0.64) | TOP1RECQLTDP1MEN1ALDH1A1 | |
| SCHEMBL16812227 | 0.81 | TOP1 (0.54) | TOP1MEN1ALDH1A1GLAKMT2A | |
| SCHEMBL14576559 | 0.80 | TOP1 (0.62) | TOP1RECQLTDP1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458170-B2 | Compound of camptothecin and preparation and use thereof | YULIANG LI (CN) | 2016-10-04 | — | — | US | disclosed |
| US-20150166559-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | Li, Yuliang (CN) | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166559-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | TOP2A, TOP2B, TYMP | TOP1 4/4885RECQL 122/4885TDP1 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.