Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | GLA | P06280 | 3/20 | 0.71 |
| ▸ | RECQL | P46063 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | STAT6 | P42226 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | GMNN | O75496 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16648942 | 0.89 | TOP1 (0.77) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL16648998 | 0.88 | TOP1 (0.73) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL16812230 | 0.87 | TOP1 (0.57) | TOP1ALDH1A1GLARECQLTDP1 | |
| Hydrochloric Acid SCHEMBL28012447 | 0.86 | TOP1 (0.97) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27827045 | 0.86 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL1004508 | 0.86 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL18296776 | 0.85 | TOP1 (0.78) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27367949 | 0.85 | TOP1 (0.81) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL8484231 | 0.85 | TOP1 (0.79) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL7262467 | 0.85 | TOP1 (0.79) | TOP1ALDH1A1GLARECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458170-B2 | Compound of camptothecin and preparation and use thereof | YULIANG LI (CN) | 2016-10-04 | — | — | US | disclosed |
| US-9458170-B2 | Compound of camptothecin and preparation and use thereof | YULIANG LI (CN) | 2016-10-04 | — | — | US | disclosed |
| US-9458170-B2 | Compound of camptothecin and preparation and use thereof | YULIANG LI (CN) | 2016-10-04 | — | — | US | disclosed |
| US-20150166559-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | Li, Yuliang (CN) | 2015-06-18 | — | — | US | disclosed |
| US-20150166559-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | Li, Yuliang (CN) | 2015-06-18 | — | — | US | disclosed |
| US-20150166559-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | Li, Yuliang (CN) | 2015-06-18 | — | — | US | disclosed |
| EP-2862571-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | Li, Yuliang (MN) | 2015-04-22 | — | — | EP | disclosed |
| EP-2862571-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | Li, Yuliang (MN) | 2015-04-22 | — | — | EP | disclosed |
| US-20150050714-A1 | Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation | OLIGASIS, LLC (US) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166559-A1 | COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF | TOP2A, TOP2B, TYMP | TOP1 4/4885ALDH1A1 1386/4885GLA 1438/4885 |
| US-20150050714-A1 | Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation | PHOSPHO1, PCTP, SGMS1 | TOP1 1015/4885ALDH1A1 2399/4885GLA 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.