Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 4/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16812355 | 0.91 | ALDH1A1 (0.39) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL16812493 | 0.91 | NR3C1 (0.39) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL16794702 | 0.89 | NR3C1 (0.35) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL18161034 | 0.89 | PDE1B (0.41) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL16794676 | 0.89 | PDE1B (0.40) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL24263381 | 0.88 | PDE1B (0.39) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL16794653 | 0.88 | CNR2 (0.41) | ALDH1A1POLB | |
| SCHEMBL16812354 | 0.88 | CDK5 (0.39) | PDE1BNR3C1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16812482 | 0.88 | NPC1 (0.40) | PDE1BNR3C1MEN1KMT2AALDH1A1 | |
| SCHEMBL16812486 | 0.88 | NPC1 (0.40) | PDE1BNR3C1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089143-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-06-18 | — | — | WO | disclosed |