Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MYOC | Q99972 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233404 | 0.86 | HSPB1 (0.64) | HSPB1ALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL1982719 | 0.85 | HSPB1 (0.62) | HSPB1ALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL31287925 | 0.85 | HSPB1 (0.62) | HSPB1ALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL21835328 | 0.85 | HSPB1 (0.62) | HSPB1ALDH1A1SOS1MEN1KMT2A | |
| SCHEMBL31522076 | 0.83 | MAPT (0.59) | HSPB1ALDH1A1MEN1KMT2AKDM4E | |
| 4,4'-Oxybis(Nitrobenzene) SCHEMBL134332 | 0.82 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9183872 | 0.82 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2011179 | 0.82 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11689190 | 0.82 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL25356037 | 0.82 | HSPB1 (0.58) | HSPB1ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080098-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-12-06 | — | — | EP | disclosed |
| US-9802920-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMAN-LA ROCHE INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHUGAI PHARMACEUTICAL CO. (JP) | 2016-10-20 | — | — | US | disclosed |
| WO-2015086636-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | HSPB1 967/4885ALDH1A1 3931/4885SOS1 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.