Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 13/20 | 0.54 |
| ▸ | L3MBTL3 | Q96JM7 | 12/20 | 0.54 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.54 |
| ▸ | NCF1 | P14598 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111729 | 0.83 | NCF1 (0.72) | L3MBTL1NCF1ALDH1A1HRH3 | |
| SCHEMBL110730 | 0.81 | NCF1 (0.70) | L3MBTL1NCF1ALDH1A1HRH3 | |
| SCHEMBL16814951 | 0.81 | NCF1 (0.70) | L3MBTL1NCF1ALDH1A1HRH3 | |
| SCHEMBL28753504 | 0.80 | NCF1 (0.55) | NCF1ALDH1A1TSHR | |
| SCHEMBL16814882 | 0.79 | NCF1 (0.77) | L3MBTL1NCF1ALDH1A1 | |
| SCHEMBL27834649 | 0.79 | NCF1 (0.71) | NCF1ALDH1A1 | |
| SCHEMBL24018758 | 0.79 | MEN1 (0.62) | NCF1ALDH1A1TSHR | |
| SCHEMBL16814993 | 0.79 | NCF1 (0.54) | NCF1ALDH1A1 | |
| SCHEMBL14207191 | 0.79 | KEAP1 (0.65) | L3MBTL1L3MBTL3MBTD1ALDH1A1TSHR | |
| SCHEMBL27665916 | 0.79 | NCF1 (0.54) | NCF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |