Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11042825 | 0.86 | PKM (0.51) | PKMCYP4F2CYP4A11HSD11B1GAA | |
| SCHEMBL68340 | 0.82 | PKM (0.60) | PKMCYP4F2CYP4A11L3MBTL1KMT2A | |
| SCHEMBL8887309 | 0.82 | PKM (0.45) | PKMCYP4F2CYP4A11HSD11B1GAA | |
| SCHEMBL11043794 | 0.80 | PKM (0.43) | PKMCYP4F2CYP4A11HSD11B1GAA | |
| SCHEMBL167924 | 0.80 | MMP2 (0.57) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL31424955 | 0.79 | PKM (0.57) | PKMCYP4F2CYP4A11L3MBTL1KMT2A | |
| SCHEMBL31424953 | 0.79 | PKM (0.57) | PKMCYP4F2CYP4A11L3MBTL1KMT2A | |
| SCHEMBL6878047 | 0.79 | PKM (0.57) | PKMCYP4F2CYP4A11L3MBTL1KMT2A | |
| SCHEMBL28247232 | 0.78 | MMP2 (0.41) | HSD11B1KMT2AALDH1A1MMP2MMP8 | |
| SCHEMBL1107140 | 0.78 | PKM (0.55) | PKMCYP4F2CYP4A11GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |