Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 13/20 | 0.43 |
| ▸ | ACACA | Q13085 | 13/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16817400 | 1.00 | ACACB (0.43) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL16817398 | 1.00 | ACACB (0.43) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL16817587 | 0.85 | ABCC1 (0.41) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL16817586 | 0.85 | ABCC1 (0.41) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL16848895 | 0.77 | MAPT (0.54) | LMNACXCR2KDM4EMEN1ALDH1A1 | |
| SCHEMBL3497629 | 0.77 | ABCC1 (0.55) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL16817608 | 0.76 | MAPT (0.49) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL1098305 | 0.72 | MEN1 (0.41) | ACACBACACAABCC1LMNAMAPK1 | |
| SCHEMBL14317217 | 0.71 | MAPT (0.46) | MAPK1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL16817403 | 0.69 | FABP4 (0.53) | ABCC1LMNAMAPK1ABCG2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604977-B2 | Bicyclic thiophenylamide compounds | HOFFMAN-LA ROCHE INC. (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2861574-B1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-20150175594-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175594-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | NAT1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, BICRA | ACACB 2908/4885ACACA 1975/4885ABCC1 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.