Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13631324 | 0.78 | ALDH1A1 (0.56) | MAPTHSD17B10KDM4EALDH1A1FLT3 | |
| SCHEMBL12057595 | 0.78 | PTPN1 (0.62) | MAPTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL16817398 | 0.77 | ACACB (0.43) | MAPTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL16817400 | 0.77 | ACACB (0.43) | MAPTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL16817396 | 0.77 | ACACB (0.43) | MAPTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12057606 | 0.77 | PTPN1 (0.63) | MAPTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12057605 | 0.76 | MAPT (0.74) | MAPTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12057591 | 0.72 | ALDH1A1 (0.58) | MAPTHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL12057607 | 0.72 | ALDH1A1 (0.58) | MAPTHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL16848805 | 0.71 | ALDH1A1 (0.50) | MAPTHSD17B10KDM4EALDH1A1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604977-B2 | Bicyclic thiophenylamide compounds | HOFFMAN-LA ROCHE INC. (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2861574-B1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-20150175594-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175594-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | NAT1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, BICRA | MAPT 2436/4885HSD17B10 2976/4885KDM4E 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.