Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16819970 | 1.00 | ROCK2 (0.43) | ROCK2JAK3ROCK1IKBKBJAK1 | |
| SCHEMBL16820011 | 0.85 | HDAC3 (0.51) | LTB4RNAMPTHDAC3NCOR2HDAC1 | |
| SCHEMBL16819996 | 0.85 | HDAC3 (0.51) | LTB4RNAMPTHDAC3NCOR2HDAC1 | |
| SCHEMBL16820010 | 0.80 | RORC (0.38) | CA1CA2CA12CA9RORC | |
| SCHEMBL16845461 | 0.80 | RORC (0.38) | CA1CA2CA12CA9RORC | |
| SCHEMBL16819916 | 0.79 | SOS1 (0.38) | CA1CA2CA12RORCCA7 | |
| SCHEMBL16819968 | 0.79 | SOS1 (0.38) | CA1CA2CA12RORCCA7 | |
| SCHEMBL16845356 | 0.77 | CA1 (0.59) | NAMPTCYP3A4HDAC3NCOR2HDAC1 | |
| SCHEMBL15557284 | 0.77 | CA1 (0.59) | NAMPTCYP3A4HDAC3NCOR2HDAC1 | |
| SCHEMBL16819926 | 0.77 | CA1 (0.59) | NAMPTCYP3A4HDAC3NCOR2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111728961-B | Medicine composition for treating senile dementia and application thereof | 牡丹江医学院 | 2021-06-15 | — | — | CN | claimed |
| CN-111728961-A | Medicine composition for treating senile dementia and application thereof | 牡丹江医学院 | 2020-10-02 | — | — | CN | claimed |
| CN-111728961-B | Medicine composition for treating senile dementia and application thereof | 牡丹江医学院 | 2021-06-15 | — | — | CN | disclosed |
| CN-111728961-B | Medicine composition for treating senile dementia and application thereof | 牡丹江医学院 | 2021-06-15 | — | — | CN | disclosed |
| CN-111728961-A | Medicine composition for treating senile dementia and application thereof | 牡丹江医学院 | 2020-10-02 | — | — | CN | disclosed |
| CN-111728961-A | Medicine composition for treating senile dementia and application thereof | 牡丹江医学院 | 2020-10-02 | — | — | CN | disclosed |
| EP-2888229-B1 | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-02-06 | — | — | EP | disclosed |
| EP-2888229-B1 | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-02-06 | — | — | EP | disclosed |
| US-9790173-B2 | Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof-I | MERCK SHARP & DOHME CORP. (US) | 2017-10-17 | — | — | US | disclosed |
| US-9790173-B2 | Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof-I | MERCK SHARP & DOHME CORP. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170158628-A1 | ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I | MERCK SHARP & DOHME CORP. (US) | 2017-06-08 | — | — | US | disclosed |
| US-20170158628-A1 | ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I | MERCK SHARP & DOHME CORP. (US) | 2017-06-08 | — | — | US | disclosed |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | MERCK SHARP & DOHME CORP. | 2015-06-25 | — | — | US | disclosed |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | MERCK SHARP & DOHME CORP. | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158628-A1 | ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I | CHRNA7, CHRNA5, CHRNA6 | ROCK2 3080/4885JAK3 3295/4885ROCK1 2164/4885 |
| US-20150175534-A1 | Alpha-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEROF-I | CHRNA7, CHRNA6, CHRNA5 | ROCK2 4250/4885JAK3 3903/4885ROCK1 3661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.