Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413993 | 0.81 | MAPT (0.66) | MAPTALDH1A1GAAHPGDKDM4E | |
| SCHEMBL4087590 | 0.77 | MAPT (0.68) | IKBKBMAPTALDH1A1GAAHPGD | |
| SCHEMBL5898668 | 0.76 | PTK2 (0.54) | IKBKBMAPTALDH1A1GAAKDM4E | |
| SCHEMBL3510525 | 0.76 | IKBKB (1.00) | IKBKBMAPTALDH1A1GAAHPGD | |
| Carbamic Acid SCHEMBL9378352 | 0.73 | KDM4E (0.52) | MAPTALDH1A1GAAHPGDKDM4E | |
| SCHEMBL613585 | 0.73 | IKBKB (0.71) | IKBKBMAPTALDH1A1GAAHPGD | |
| SCHEMBL3509823 | 0.73 | IKBKB (0.66) | IKBKBMAPTALDH1A1GAAHPGD | |
| SCHEMBL13613456 | 0.73 | CHEK1 (0.57) | CDC7CHEK1CHEK2 | |
| SCHEMBL3561581 | 0.72 | KCNH2 (0.62) | IKBKBHDAC1HDAC3HDAC2 | |
| SCHEMBL5898679 | 0.72 | IKBKB (0.64) | IKBKBMAPTALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046793-A1 | NOVEL JAK3 INHIBITOR CONTAINING, AS ACTIVE INGREDIENT, THIOPHENE DERIVATIVE HAVING UREIDO GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | 参天製薬株式会社 (JP) | 2012-04-12 | — | — | WO | disclosed |